Asymmetric epoxidation and kinetic resolution of allylic phosphine oxides

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Jonathan Clayden and Stuart Warren


Abstract

Allylic alcohols bearing a diphenylphosphinoyl group undergo asymmetric epoxidation with excellent enantioselectivity, and can undergo kinetic resolution with good diastereoselectivity, with the diphenylphosphinoyl group exerting an anti-directing effect on the epoxidation.


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