Issue 13, 1994

Regioselective hydrolysis of aromatic dinitriles using a whole cell catalyst

Abstract

A series of aromatic dinitriles have been examined as substrates for an immobilised whole cell Rhodococcus sp. that catalyses the hydrolysis of nitrites to amides and/or carboxylic acids. The fluorinated aromatic dinitriles 48 and 49 were regioselectively hydrolysed to the corresponding cyano amides 48a and 49a whereas the non-fluorinated analogues 41–44 were converted to cyano acids but with poorer regioselectivity.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1994, 1679-1687

Regioselective hydrolysis of aromatic dinitriles using a whole cell catalyst

J. Crosby, J. Moilliet, J. S. Parratt and N. J. Turner, J. Chem. Soc., Perkin Trans. 1, 1994, 1679 DOI: 10.1039/P19940001679

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