An efficient general route to furo-, pyrido- and thieno-[d][2]benzazepines via Pd0 catalysed cross coupling reactions and nitrile ylide cyclisations

Abstract

The cyclisation of diene-conjugated nitrile ylides of the general type 1, in which the conjugated system consists of a benzene ring and a five- or a six-membered heterocyclic ring, provides an effective route to fully unsaturated heterocyclo[d][2]benzazepines. The combination of this cyclisation with a direct route to the nitrile ylide precursors via Pd⁰ catalysed cross-coupling gives an efficient general synthetic route to these systems from readily available starting materials.