Optically pure 4-formyl-3-hydroxy β-lactams are transformed into 4-methylaryl and 4-(2-ethylaryl) derivatives and converted into β-substituted alanine-derived NCAs through oxidation and Baeyer–Villiger rearrangement of the resulting α-keto β-lactams.
C. Palomo, J. M. Aizpurua, I. Ganboa, E. Maneiro and B. Odriozola, J. Chem. Soc., Chem. Commun., 1994, 1505 DOI: 10.1039/C39940001505
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