Preparation of activated nucleotides and their phosphorothioate and phosphorodithioate analogues
Abstract
The preparation of nucleoside phosphoro-(1,2,4-triazolides)(e.g.9a) and their thio-and dithio-analogues (e.g.9b and c, respectively), and a corresponding set of activated nucleotides (e.g.10a, b, c) derived from 1-hydroxybenzotriazole is described; the reactions between these derivatives and methylamine are also reported.