Compounds with bridgehead nitrogen part 71. Stereochemistry of protonated perhydropyrido[1,2-c][1,3]benzoxazepines

Abstract

Protonation of syn-perhydropyrido[1,2-c][1,3]benzoxazepines in CDCl₃ solution by hydrogen chloride gas gives predominantly the trans-A/B ring fused hydrochloride salts. The corresponding anti-compounds give mixtures of hydrochlorides containing substantial amounts of the cis-salt. This latter compound prefers the O-outside cis-fused conformation.