Preparation and reactivity of cuprate derivatives of lithium 6-lithiopiperonylate with tricarbonyl(2-methoxycyclohexadienyl)iron(1+) hexafluorophosphate(1–)

Abstract

Arylcuprate species derived from 6-bromopiperonylic acid have been prepared, and evaluated as nucleophiles in reactions with tricarbonyl(2-methoxycyclohexadienyl)iron(1+) hexafluorophosphate(1–). Use of CuCN in place of Cul for the preparation of the arylcuprate species, gave improved yields of the products obtained from C–C bond formation. Furthermore, by preparing the arylcuprate species at low temperature, competing orthometallation processes were avoided.