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DOI: 10.1039/C39930001790 (Paper) Reference Section for: J. Chem. Soc., Chem. Commun., 1993, 1790-1792

Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide; asymmetric synthesis of a C1–C8δ-lactone subunit

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Ian Paterson and Stephen P. Wren

Abstract

The stereoselective, boron-mediated, aldol/reduction sequence, 4+5→8→9, allows an efficient asymmetric synthesis of the δ-lactone-containina. C1–C8 subunit 2 of discodermolide 1.

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