A strategy for a total synthesis of the immunosuppressant agent rapamycin 1 is outlined and the stereoselective construction of a suitably functionalized C8–C18 fragment 2 is described.
A. D. Piscopio, N. Minowa, T. K. Chakraborty, K. Koide, P. Bertinato and K. C. Nicolaou, J. Chem. Soc., Chem. Commun., 1993, 617 DOI: 10.1039/C39930000617
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