Steric acceleration of intramolecular azide cycloadditions
Abstract
Use of conformational restraints, induced by different ortho-substituents in 1-allyloxy- and 1-prop-2-ynyloxy-2-azidomethylbenzenes, can be employed to enhance the smooth intramolecular addition of the azide group to the unsaturated bond, followed by, in one example, removal of the conformational constraint.