New CF2-containing building blocks, ethyl 3-ethoxy-2,2-difluoro-3-hydroxy-propionate and -propioamide, were prepared via formylation of α,α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides.
T. Tsukamoto and T. Kitazume, J. Chem. Soc., Chem. Commun., 1992, 540 DOI: 10.1039/C39920000540
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