Application of flow-through techniques to drug dissolution studies

Abstract

Two flow-through techniques, i.e., flow injection and triangle programmed flow titrimetry, have been used to follow the dissolution of durgs from pharmaceutical preparations. The applicability of direct ultraviolet spectrophotometry as a detection technique in flow injection was demonstrated for dissolution studies of nitrazepam- and metronidazole-containing pharmaceutical preparations. In the application of the triangle programmed titration technique, the dissolution of promethazine and ampicillin from pharmaceutical preparations was studied.