Effects of differing chirality on the hydrogen-bonding behaviour of di- and tri-peptide derivatives

Abstract

The self-association of di- and tri-peptide derivatives with a well-defined configuration at their chiral C atoms and 1 : 1 mixed diastereoisomeric pairs of these tripeptide derivatives have been investigated by means of IR spectroscopy in CH₂Cl₂. In most–but not in all–cases major differences in the association behaviour have been recorded on changing the configuration at only one C atom.