Issue 6, 1990

Olivanic acid analogues. Part 6. Biomimetic synthesis of (±)-PS-5, (±)-6-Epi-PS-5, and (±)-benzyl MM22381

Abstract

Michael addition of thiols to 6-substituted azabicyclo[3.2.0]hept-2-ene-2-carboxylates, followed by reintroduction of the double bond with iodobenzene dichloride–pyridine under anhydrous conditions, provides a biomimetic strategy for the synthesis of 3-alkylthio-substituted olivanic acids (carbapenems) and their derivatives. This is illustrated by syntheses of representatives of the PS-5 and MM22381 series of antibacterial natural products.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1990, 1793-1801

Olivanic acid analogues. Part 6. Biomimetic synthesis of (±)-PS-5, (±)-6-Epi-PS-5, and (±)-benzyl MM22381

J. H. Bateson, R. I. Hickling, T. C. Smale and R. Southgate, J. Chem. Soc., Perkin Trans. 1, 1990, 1793 DOI: 10.1039/P19900001793

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