Reaction between 2-chloro-5-thiazolyl-lithium and N,N-dialkylformamides or amides gave 2-N,N-dialkylaminothiazol-5-yl aldehydes or ketones on quenching with water. Quenching with acid gave 2-chlorothiazole-5-yl aldehydes or ketones, from which chloride was easily displaced by free amines.
I. Sawhney and J. R. H. Wilson, J. Chem. Soc., Perkin Trans. 1, 1990, 329 DOI: 10.1039/P19900000329
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