2-Amino-6-chloropurines (2b)–(2e) react with trimethylamine/3-hydroxypropionitrile in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene to afford the corresponding N-9-substituted guanines (1b)–(1e) in near-quantitative yield.
M. Ashwell, C. Bleasdale, B. T. Golding and I. K. O'Neill, J. Chem. Soc., Chem. Commun., 1990, 955 DOI: 10.1039/C39900000955
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