The total synthesis of destomic acid
Abstract
1-Benzoyloxy-2-t-butyldimethylsilyloxy-4-ethoxybuta-1,3-diene (3) reacts with N-benzyloxycarbonyl-O-t-butyldiphenylsilyl-L-serinal (4) to give, with high selectivity, compound (5a) which was subsequently transformed into derivatives of destomic acid (7) and (8).