The biosynthesis of glaucine in Litsea glutinosa

Abstract

Incorporation of ¹⁴C labelled (±)-reticuline and tritiated racemic reticuline, protosinomenine, orientaline, laudanosine, isoboldine, boldine, thaliporphine, N-methyl-laurotetanine, and dicentrine into glaucine in young Litsea glutinosa(Lour) C. B. Rob. var. glabraria Hook f. (Lauraceae) has been studied. The results provide evidence that (S)-reticuline (5) is converted by oxidative coupling into (S)-isoboldine (6) and methylation via(S)-thaliporphine (7) to form (S)-glaucine (8).