Issue 0, 1987

The synthesis of heteroaromatic prostacyclin analogues via keto alkyne cyclisation

Abstract

Keto alkyne cyclisation has been used to prepare tetrahydrobenzo [b] furans (4) and (15) but cyclopenta[b]furans are not available by this procedure. Compound (15) has been converted into benzofuran prostacyclin analogues (5) and (6) by extremely short routes. Conditions are also described for the conversion of the same keto alkynes into tetrahydrobenzo[b]- and cyclopenta[b]- thiophenes and -pyrroles, (7a,b) and (9a,b). Syntheses of thiophene prostacyclin analogues (8a) and (8b) are also discussed.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1987, 1825-1831

The synthesis of heteroaromatic prostacyclin analogues via keto alkyne cyclisation

S. Cook, D. Henderson, K. A. Richardson, R. J. K. Taylor, J. Saunders and P. G. Strange, J. Chem. Soc., Perkin Trans. 1, 1987, 1825 DOI: 10.1039/P19870001825

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