An efficient microbial resolution of 1,3-diphenylpropane-1,3-diol (4) has been achieved by exposing the corresponding diacetate to Trichoderma viride; a reductive cleavage of chiral acetals (6) derived from (4) with hydride reagent (Br2AlH, Cl2AlH) affords optically active alcohols (8) of high enantiomeric purities.
K. Yamamoto, H. Ando and H. Chikamatsu, J. Chem. Soc., Chem. Commun., 1987, 334 DOI: 10.1039/C39870000334
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