Synthesis of (+)-carbacyclin based on a new chiral induction procedure
Abstract
The chiral bicyclic β-keto ester (14), which is synthesised by our methods involving stereoselective differentiation between two identical groups in the diamide (4) of (R)-4-methoxycarbonyl-1,3-thiazolidine-2-thione and regiocontrolled Dieckmann-type cyclisation of half-thiol diester (11), has been successfully converted into (+)-carbacyclin (2).