New α-amino ketones (5) derived from leucine have been synthesized by reaction of organometallics on N-methoxy-N-methylamide (4). The stereoselectivity of reduction of the α-amino ketones (5) was studied. The stereochemistry of the resulting α-amino alcohols (6) was established by transforming them into the oxazolidinones (8) by means of a new procedure.
M. Dufour, P. Jouin, J. Poncet, A. Pantaloni and B. Castro, J. Chem. Soc., Perkin Trans. 1, 1986, 1895 DOI: 10.1039/P19860001895
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