A concise synthetic route to polyfunctional γ-ketoester derivatives via methoxy(phenylthio)methyl-lithium
Abstract
The α,β-unsaturated O,S-acetals obtained via the reaction of methoxyphenylthiomethyl-lithium with 3-alkoxyenones are readily convertible into structurally diverse γ-ketoesters by way of an efficient alkylation–hydrolysis sequence.