Issue 11, 1985

Electrochemical reduction of nitrofurazone and its determination in pharmaceutical dosage forms by D.c. polarography

Abstract

A d.c. polarographic method was developed for the determination of nitrofurazone in pharmaceutical formulations using individually four different buffer systems, namely acetate (pH 3.60–5.60), Mcllvaine (pH 2.20–8.00), borate (pH 7.80–10.00) and Britton-Robinson (pH 2.00–12.00). The substance was extracted from the dosage forms with 40% methanol, an appropriate buffer of selected pH was added to an aliquot and the solution then polarographed at a dropping-mercury electrode versus S.C.E. The two-step reduction waves observed were found to be irreversible and diffusion controlled. The standard additions technique provided results as satisfactory as those obtained with the use of a calibration graph.

Article information

Article type
Paper

Analyst, 1985,110, 1373-1376

Electrochemical reduction of nitrofurazone and its determination in pharmaceutical dosage forms by D.c. polarography

A. K. Mishra and K. D. Gode, Analyst, 1985, 110, 1373 DOI: 10.1039/AN9851001373

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements