Nucleophilic displacement of N-aryl and heteroaryl groups. Part 5. Conversion of 2-aminopyridines into 2-pyridones
Abstract
2-Ethoxycarbonyl-1-(2-pyridyl)pyridinium cations (3)(easily prepared from 2-aminopyridine and the appropriate pyrylium salt) are converted by dilute NaOH at 25 °C into 1-(substituted 2-pyridylcarbonyl)-2-pyridones (7). Compounds (7) are readily hydrolysed to 2-pyridones.
 
                



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