Asymmetric synthesis of glycidic 2-oxazolines
Abstract
A stereospecific synthesis of 4S,5S-(–)-2-[(2R)-2,3-epoxy-2,3-dimethylbutyl]-4-methoxymethyl-5-phenyl-2-oxazoline via a Darzens condensation of 4S, 5S-(–)-2-(1-bromoethyl)-4-methoxymethyl-5-phenyl-2-oxazoline with propan-2-one is reported.