The TiCl4-catalysed intramolecular directed aldol condensation of silyl enol ethers and acetals can be used to make 6-, 7-, and 8-membered rings; a template effect of Ti is invoked to explain the formation of medium rings.
G. S. Cockerill and P. Kocienski, J. Chem. Soc., Chem. Commun., 1983, 705 DOI: 10.1039/C39830000705
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