Synthesis of γ-aminobutyric acid analogues of restricted conformation. Part 1. The 2-aminocycloalkylacetic acids
Abstract
The syntheses of cis- and trans-2-aminocyclopropyl, -cyclobutyl, -cyclopentyl, and -cyclohexylacetic acids as γ-aminobutyric acid analogues of restricted conformation are described. Mass spectral evidence fully supports the stereochemical assignments of the configurational isomers.