The ynolate 1-lithio-oxy-2-phenylacetylene, prepared from 3,4-diphenylisoxazole and n-butyl-lithium in tetrahydrofuran at –78 °C, condensed with the electron deficient imines (R1N![[double bond, length half m-dash]](https://www.rsc.org/images/entities/char_e006.gif)
CHR2) to give the β-lactams [R1NHCH(R2)[graphic omitted]HR2](R1= C6H4NO2-4 and C6H4CO2Et-4; R2= Ph, C6H4Me-3 and C6H4NO2-4).
A. G. M. Barrett and P. Quayle, J. Chem. Soc., Perkin Trans. 1, 1982, 2193 DOI: 10.1039/P19820002193
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