Absolute configuration of a chiral N-chloroaziridine with molecular asymmetry due solely to a trivalent nitrogen atom. X-Ray structure of (R)-(–)-1-chloro-2,2-diphenylaziridine

Abstract

X-Ray analysis of the crystalline optically active 1-chloro-2,2-diphenylaziridine, obtained by chlorination of 2,2-diphenylaziridine with t-butyl hypochlorite in the presence of a chiral trifluoro-alcohol, followed by fractional crystallization of the crude reaction product, shows that the absolute configuration at the chiral nitrogen atom of the derivative is (–)-(R).