The fast Cu2+-promoted hydrolysis of the two macrocyclic nitriles (3) and (4) is due to the proximity of the reactants allowing an intramolecular nucleophilic attack of the co-ordinated OH– on the cyano-group to take place.
W. Schibler and T. A. Kaden, J. Chem. Soc., Chem. Commun., 1981, 603 DOI: 10.1039/C39810000603
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