The reaction of equivalent amounts of N-benzyl-oxycarbonyl-L-valine and N,N′-di-isopropylcarbodi-imide in deuteriochloroform gives an equimolar mixture of the symmetrical anhydride of the N-protected amino-acid, N,N″-di-isopropylurea, and unchanged carbodi-imide and not the O-acylisourea adduct as reported in the literature.
N. L. Benoiton and F. M. F. Chen, J. Chem. Soc., Chem. Commun., 1981, 543 DOI: 10.1039/C39810000543
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