Effective method for the asymmetric synthesis of bis-β-lactams by the cycloaddition of azidoketen to benzylideneamines bearing a chiral β-lactam backbone
Abstract
Extremely high stereoselectivity was observed in the asymmetric cycloaddition of azidoketen to 1-[(S)-1-t-butoxycarbonylethyl]-3-benzylideneamino-4-phenyl-azetidin-2-ones, which gave rise to the formation of optically pure bis-β-lactams.