A systematic variation of the structure of a transition-state analogue of aspartate transcarbamylase has been carried out. A new, and general, synthesis of these analogues, starting from the appropriate amino-acid is described.
J. J. Goodson, C. J. Wharton and R. Wrigglesworth, J. Chem. Soc., Perkin Trans. 1, 1980, 2721 DOI: 10.1039/P19800002721
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