Cotinine and other nicotine derivatives have been converted to 9aH- and 4H-quinolizines by dimethyl acetylenedicarboxylate, while cotinine itself by a series of steps has yielded 6-(1-methyl-5-oxopyrrolidin-2-yl)indolizine.
R. M. Acheson, M. J. Ferris and N. M. Sinclair, J. Chem. Soc., Perkin Trans. 1, 1980, 78 DOI: 10.1039/P19800000078
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