Formation of the hemi-acetal ring in the sesquiterpenoid, dihydrobotrydial
Abstract
The formation of the hemi-acetal ring of dihydrobotrydial occurs with the retention of the pro-2(R) and pro-5(R) mevalonoid hydrogen atoms at C–15 and C–10, respectively, and proceeds with overall retention of configuration from farnesyl pyrophosphate at these centres via the corresponding dialdehyde.