Asymmetric reduction of prochiral aromatic ketones with reagents prepared from sodium borohydride and Lewis acids in the presence of 1,2:5,6-di-O-iso-propylidene-α-D-glucofuranose
Abstract
Asymmetric reduction of aromatic ketones with reagents formed from sodium borohydride and various Lewis acids in the presence of 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose afforded the corresponding phenyl carbinols in reasonably good optical yields (up to 88%).