Ellipticine has been synthesised from 1-phenyl-sulphonylindol-2-yl 3-acetylpyridin-4-yl ketone by introducing the C-5-methyl via a Wittig reaction and catalytic reduction after selective protection of the acetyl carbonyl; acidic removal of the acetal group then led directly to the alkaloid.
D. A. Taylor and J. A. Joule, J. Chem. Soc., Chem. Commun., 1979, 642 DOI: 10.1039/C39790000642
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