The reduction by di-isobutylaluminium hydride of N-blocked amino acid imidazolides gives good yields of α-acylamino aldehydes, the optical purity of which is higher than those previously reported, but a check of one aldehyde prepared showed only 60% optical purity; the chemical shifts at the aldehydo 13C and 1H resonances are reported.
H. Khatri and C. H. Stammer, J. Chem. Soc., Chem. Commun., 1979, 79 DOI: 10.1039/C39790000079
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