Assay of nicotinamide in multivitamin preparations using an ammonia gas-sensing electrode

Abstract

A simple potentiometric method for the determination of nicotinamide is described. The sample is subjected to alkaline hydrolysis and the ammonia thus produced is determined with an ammonia gas-sensing electrode. Amounts of nicotinamide in the range 0.5–15 mg have been determined with an average error of about 1.7%. The method has been applied to the analysis of multivitamin preparations. The analytical recovery of nicotinamide was 95–107%. Comparison with an official method gave satisfactory results.