Determination of the prostaglandin F2α content of pharmaceutical preparations with triangle programmed bromimetric titration in flowing solutions

Abstract

A survey of the different methods for prostaglandin analysis is given. The use of bromine as a reagent for the accurate determination of prostaglandin F_2α is indicated from its chemical structure. Several reasons, however, hinder the use of classical bromimetry.

In this paper the application of a new analytical method, the so-called triangle programmed titration technique, is described for prostaglandin analysis. This method permits the simple and effective use of bromine as a reagent by performing the titration in a continuous-flow system. The reagent is generated coulometrically during the titration.

Methods are described for the determination of the prostaglandin F_2α content of different pharmaceutical preparations.