Analysis of steroids. Part XXXII. Determination of allyloestrenol by titrimetric, polarographic and gas-chromatographic methods

Abstract

A titrimetric method is described for the determination of allyloestrenol based on methoxymercuration of its double bonds and titration of the acetic acid formed with standard sodium hydroxide solution. The relative standard deviation of the method is 0.29%. The polarographic reduction of the mercury addition compound on the dropping-mercury electrode is used for the determination of allyloestrenol in a tablet formulation with a relative standard deviation of 3.1%. A gas-chromatographic method with a relative standard deviation of 1.5% is also described. The applicability of these methods to the determination of the stability of allyloestrenol and of its dosage form is discussed.