The mesitylene-2-sulphonyl (Mts) group attached at the guanidino function of arginine can be quantitatively cleaved by methanesulphonic acid, as well as trifluoromethanesulphonic acid and hydrogen fluoride; this new Arg(Mts) derivative was successfully applied to the synthesis of hypothalamic substance P.
H. Yajima, M. Takeyama, J. Kanaki and K. Mitani, J. Chem. Soc., Chem. Commun., 1978, 482 DOI: 10.1039/C39780000482
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