DOI: 10.1039/P19770000550
(Paper)
J. Chem. Soc., Perkin Trans. 1, 1977, 550-565
Regioselectivity and control in alkene formation from a carbonium ion after diphenylphosphinoyl migration
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Alan H. Davidson, Ian Fleming, J. Ian Grayson, Andrew Pearce, Roger L. Snowden and Stuart Warren
Abstract
Conversion of 2-hydroxyalkyldiphenylphosphine oxides into allylphosphine oxides by acid-catalysed diphenyl-phosphinoyl migration shows complete regioselectivity in favour of the more substituted olefin when the migration origin is unsymmetrical. The other, less substituted olefin is formed exclusively when a trimethylsilyl group is present on the appropriate carbon atom as it both increases the rate of the rearrangement and is lost in preference to a proton. The allylphosphine oxides are used in diene synthesis.