Some 2-(4-substituted phenyl)thiophens and their 3-methyl derivatives have been used to prepare substituted methylamines, ethylamines, and acetic acids with potential biological activity. Similar derivatives from 3-phenylthiophen and its 2-methyl derivative have also been prepared. Electrophilic substitution of 3-methyl-2-phenylthiophen and of 2-methyl-3-phenylthiophen takes place in the vacant α-position of the thiophen ring.
C. M. Beaton, N. B. Chapman, K. Clarke and J. M. Willis, J. Chem. Soc., Perkin Trans. 1, 1976, 2355 DOI: 10.1039/P19760002355
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