Formation of optically active amino-acids. Part VII. An electrochemical synthesis of dichlorobutyrines

Abstract

γγ-Dichloro-L-butyrines (armentomycin and its derivatives) have been synthesized electrochemically from γγγ-trichloro-L-butyrines without racemization. This method has been extended to a synthesis of βγ-unsaturated γγ-dichloro-L-butyrines and threo-γγ-dichloro-β-hydroxy-DL-butyrines, which are interesting as armentomycin analogues.