Hydroxydenitration by a Nef-type process; the more general case
Abstract
With CN– anions in dipolar aprotic solvents 2- and 4-nitroisophthalonitriles yield 2- and 4-hydroxy-iso-phthalonitriles through an induced Nef-type disruption of the nitro-group; halide ions (Br– and I–) under the same conditions yield 5-halogeno-2-hydroxy- and 5-halogeno-4-hydroxy-isophthalonitrile, respectively.