Issue 13, 1975

Transformations of penicillins: reactions with chloramine T

Abstract

Reaction of chloramine T trihydrate with certain 6β-amidopenicillanates affords β-lactam-fused thiadiazine S-imides. The structure of one S-imide was established by X-ray crystallography and those of the others were deduced by spectroscopic comparison. Penicillanates lacking a secondary amide group at C-6 did not undergo comparable reaction. The β-lactam-fused heterocyclic S-imides were particularly stable towards a series of reactants, including oxidising and reducing reagents. Trichloroethyl 6β-phenylacetamidopenicillanate was significantly different in its reactivity towards chloramine T, affording β-lactam-fused oxazolines and a monocylic chlorozetidinone. A by-product in these reactions was identified as NN′-thiobis(toluene-p-sulphonamide).

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1975, 1208-1212

Transformations of penicillins: reactions with chloramine T

M. M. Campbell, G. Johnson, A. F. Cameron and I. R. Cameron, J. Chem. Soc., Perkin Trans. 1, 1975, 1208 DOI: 10.1039/P19750001208

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