Issue 0, 1974

Syntheses of heterocyclic compounds. Part XXIX. Substituted 2,3-dihydro-1H-1,5-benzodiazepines

Abstract

1,5-Benzodiazepine-2-spirocycloalkanes [as (6)] are made in a one-step condensation from o-phenylenediamine and cyclic ketones in cold ethanol in the presence of boron trifluoride–ether complex. The method is also applicable to acyclic ketones. The diazepines can also be prepared from the monohydrochloride of the base with a liquid ketone. Acylation, hydrolysis, reduction, and oxidation of some of these novel diazepines have been studied.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1974, 2657-2661

Syntheses of heterocyclic compounds. Part XXIX. Substituted 2,3-dihydro-1H-1,5-benzodiazepines

J. A. L. Herbert and H. Suschitzky, J. Chem. Soc., Perkin Trans. 1, 1974, 2657 DOI: 10.1039/P19740002657

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements