A new type of nucleophilic substitution with a concomitant migration to an allylic position. From 5-bromo-6-methyluracils to 6-(substituted methyl)uracils
Abstract
1-Substituted or 1,3-disubstituted 5-bromo-6-methyluracil derivatives react with nucleophiles such as aromatic amines and sodium acylates to yield 6-aryl-aminomethyl- and 6-acyloxymethyl-uracils.